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TIME
In a first, scientist led by Kamel Khalili, director of the Comprehensive NeuroAIDS Center at Temple University, report in the journal Gene Therapy that they have for the first time successfully eliminated HIV genes from the genomes of mice and rats infected with the virus.
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ScienceDaily
The visible impacts of depression and stress that can be seen in a person's face — and contribute to shorter lives — can also be found in alterations in genetic activity, according to newly published research. In a series of studies involving both C. elegans worms and human cohorts, researchers from the Indiana University School of Medicine and the Scripps Research Institute have identified a series of genes that may modulate the effects of good or bad mood and response to stress on lifespan.
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University of Toronto via ScienceDaily
What used to be dismissed by many as "junk DNA" is back with a vengeance as growing data points to the importance of non-coding RNAs — genome's messages that do not code for proteins — in development and disease. Researchers have developed a method that enables scientists to explore in depth what ncRNAs do in human cells.
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Discovery News
Ski-jump, hooked, piggy or snubbed — there are almost as many nose shapes as there are people in the world. Now, new research has uncovered four genes that govern some of the variation in the human olfactory organ.
The new findings could help scientists understand the roots of this variation, the researchers said.
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| BIOTECH/DIAGNOSTICS/PERSONALIZED MEDICINE |
Medscape
A large meta-analysis of phase 1 clinical trials found that patients for whom a personalized, biomarker-based selection strategy was used had significantly better outcomes than patients for whom a biomarker-based approach was not used.
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Health Information Designs
With the pharmaceutical industry shifting focus away from manufacturing its traditional, well-known and widely used drugs — many of which will lose exclusivity over approximately the next five years — how will the turn toward orphan drugs affect overall pharmacy expenditures? Understanding the nature of orphan drugs and the reasons for their increasing prominence can help point to an answer.
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Medical Xpress
Upbringing and circumstance — and the consequences of a lifetime of decisions — all shape us to varying degrees. And the environment undoubtedly plays some role. But, at the core of it all is our genetics, the foundational biologic blueprint of our physical — and psychological — being.
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| EMERGING MEDICAL TECHNOLOGIES |
Reuters via Fox News
Israeli 3-D printer firm Nano Dimension has successfully lab-tested a 3-D bioprinter for stem cells, paving the way for the potential printing of large tissues and organs, the company said on Wednesday.
While 3-D printers are used already to create stem cells for research, Nano Dimension said the trial, conducted with Israeli biotech firm Accellta Ltd., showed its adapted printer could make large volumes of high resolution cells quickly.
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Forbes
Do doctors know enough about medical technology to help start building the software that they use inside their practices? Traditional thinking would say, no. The medical trade might be modernizing, but its members generally know more about kidneys than keyboards and more colons, corneas and clavicles than CAPS lock.
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CBS News
An experimental procedure aimed at repairing spinal cord injuries is showing promise. It uses stem cells in the damaged areas in hopes of restoring function and movement.
And for one patient, it is promising.
On April 9, 2013, James Mason was an accident waiting to happen.
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Genoptix, a Novartis company, is a leading CAP-accredited and CLIA-certified specialized laboratory focused on delivering diagnostic services to hematology/oncology patients and the physicians who treat them.
800.755.1605 / www.genoptix.com MORE
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ArsTechnica
It all started because Amy Karle wanted to grow her own exoskeleton. But after experimenting with 3-D printing bones during an artist residency program through Autodesk's Pier 9 workshop in San Francisco, she set her sights on something a little smaller and more intimate. She decided to grow a human hand.
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| ACCOUNTABLE CARE ORGANIZATIONS |
Health IT Analytics
There is no standard recipe for success when it comes to developing an accountable care organization that can earn incentives through the Medicare Shared Savings Program. The checkered history of the initiative, which has faced an onslaught of criticism about its benchmarking methodologies and lackluster financial returns, may not seem all that appealing to an organization that is seeking to reach the next level of patient engagement and populate health management.
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| FDA: NEW TREATMENTS AND TECHNOLOGY |
New York Times
The Food and Drug Administration approved a new immunotherapy drug from Roche to treat bladder cancer, a form of cancer for which there have been no significant new medicines in years. The drug, called Tecentriq, is the fourth medicine of a new class called checkpoint inhibitors that work by unleashing the body’s immune system to attack tumors.
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NPR
Amid a raging opioid epidemic, many doctors and families in the U.S. have been pleading for better treatment alternatives. One option now under consideration by the Food and Drug Administration is a system of implanted rods that offer controlled release of buprenorphine — a drug already used in other forms to treat opioid addiction.
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HealthLeaders Media
Survey respondents are under no illusion that consumers will benefit. Only 10 percent believe payer consolidation will result in lower consumer healthcare costs, and even fewer believe patients will receive a higher quality of care.
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Merrimack Announces Inclusion of ONIVYDE(R) (irinotecan liposome injection) as a Category 1 Treatment Option in the 2016 NCCN Guidelines for Pancreatic Adenocarcinoma. Please click here to view the entire press release.
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We wanted you to be aware that the FDA has approved a new indication for IBRANCE (palbociclib) 125mg capsules. Click here to read the press release. |
Check out JMCM’s new website at www.jmcmpub.org
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Seattle Genetics Announces FDA Regular Approval of ADCETRIS® for Classical Hodgkin Lymphoma Patients at High Risk of Relapse or Progression. Click here to view more information. |
Sandoz, a Novartis company, announced today that Zarxio(TM) (filgrastim-sndz) is now available in the United States. Zarxio is the first biosimilar approved by the US Food and Drug Administration (FDA) and the first to launch in the US. Please click here for more information.
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